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Exosome-like silica nanoparticles: A novel ultrasound contrast agent for stem cell imaging
Chen, Fang1,2; Ma, Ming3; Wang, Junxin1; Wang, Fang4; Chern, Shi-Xiong3; Zhao, Eric Ruike1; Jhunjhunwala, Anamik5; Darmadi, Sean1; Chen, Hangrong3; Jokerst, Jesse V.1,2
2017
Source PublicationNanoscale
ISSN20403364
Volume9Issue:1Pages:402-411
AbstractUltrasound is critical in many areas of medicine including obstetrics, oncology, and cardiology with emerging applications in regenerative medicine. However, one critical limitation of ultrasound is the low contrast of target tissue over background. Here, we describe a novel cup-shaped silica nanoparticle that is reminiscent of exosomes and that has significant ultrasound impedance mismatch for labelling stem cells for regenerative medicine imaging. These exosome-like silica nanoparticles (ELS) were created through emulsion templating and the silica precursors bis(triethoxysilyl)ethane (BTSE) and bis(3-trimethoxysilyl-propyl)amine (TSPA). We found that 40% TSPA resulted in the exosome like-morphology and a positive charge suitable for labelling mesenchymal stem cells. We then compared this novel structure to other silica structures used in ultrasound including Stober silica nanoparticles (SSN), MCM-41 mesoporous silica nanoparticles (MSN), and mesocellular foam silica nanoparticles (MCF) and found that the ELS offered enhanced stem cell signal due to its positive charge to facilitate cell uptake as well as inherently increased echogenicity. The in vivo detection limits were © 2017 The Royal Society of Chemistry.
DOI10.1039/c6nr08177k
EI Accession Number20170103207806
EI KeywordsDrug delivery
EI Classification Number461.2 Biological Materials and Tissue Engineering - 753.3 Ultrasonic Applications - 802.3 Chemical Operations
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Document Type期刊论文
Identifierhttp://ir.sic.ac.cn/handle/331005/25550
Collection中国科学院上海硅酸盐研究所
Affiliation1.Department of NanoEngineering, University of California San Diego, 9500 Gilman Drive, San Diego; CA; 92093-0448, United States;
2.Materials Science and Engineering Program, University of California San Diego, 9500 Gilman Drive, San Diego; CA; 92093-0448, United States;
3.State Key Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai; 200050, China;
4.Research Center for Bioengineering and Sensing Technology, University of Science and Technology Beijing, Beijing; 100083, China;
5.Department of Bioengineering, University of California San Diego, 9500 Gilman Drive, San Diego; CA; 92093-0418, United States
Recommended Citation
GB/T 7714
Chen, Fang,Ma, Ming,Wang, Junxin,et al. Exosome-like silica nanoparticles: A novel ultrasound contrast agent for stem cell imaging[J]. Nanoscale,2017,9(1):402-411.
APA Chen, Fang.,Ma, Ming.,Wang, Junxin.,Wang, Fang.,Chern, Shi-Xiong.,...&Jokerst, Jesse V..(2017).Exosome-like silica nanoparticles: A novel ultrasound contrast agent for stem cell imaging.Nanoscale,9(1),402-411.
MLA Chen, Fang,et al."Exosome-like silica nanoparticles: A novel ultrasound contrast agent for stem cell imaging".Nanoscale 9.1(2017):402-411.
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