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Exosome-like silica nanoparticles: A novel ultrasound contrast agent for stem cell imaging
Chen, Fang1,2; Ma, Ming3; Wang, Junxin1; Wang, Fang4; Chern, Shi-Xiong3; Zhao, Eric Ruike1; Jhunjhunwala, Anamik5; Darmadi, Sean1; Chen, Hangrong3; Jokerst, Jesse V.1,2
2017
发表期刊Nanoscale
ISSN20403364
卷号9期号:1页码:402-411
摘要Ultrasound is critical in many areas of medicine including obstetrics, oncology, and cardiology with emerging applications in regenerative medicine. However, one critical limitation of ultrasound is the low contrast of target tissue over background. Here, we describe a novel cup-shaped silica nanoparticle that is reminiscent of exosomes and that has significant ultrasound impedance mismatch for labelling stem cells for regenerative medicine imaging. These exosome-like silica nanoparticles (ELS) were created through emulsion templating and the silica precursors bis(triethoxysilyl)ethane (BTSE) and bis(3-trimethoxysilyl-propyl)amine (TSPA). We found that 40% TSPA resulted in the exosome like-morphology and a positive charge suitable for labelling mesenchymal stem cells. We then compared this novel structure to other silica structures used in ultrasound including Stober silica nanoparticles (SSN), MCM-41 mesoporous silica nanoparticles (MSN), and mesocellular foam silica nanoparticles (MCF) and found that the ELS offered enhanced stem cell signal due to its positive charge to facilitate cell uptake as well as inherently increased echogenicity. The in vivo detection limits were © 2017 The Royal Society of Chemistry.
DOI10.1039/c6nr08177k
EI入藏号20170103207806
EI主题词Drug delivery
EI分类号461.2 Biological Materials and Tissue Engineering - 753.3 Ultrasonic Applications - 802.3 Chemical Operations
引用统计
被引频次:23[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.sic.ac.cn/handle/331005/25550
专题中国科学院上海硅酸盐研究所
作者单位1.Department of NanoEngineering, University of California San Diego, 9500 Gilman Drive, San Diego; CA; 92093-0448, United States;
2.Materials Science and Engineering Program, University of California San Diego, 9500 Gilman Drive, San Diego; CA; 92093-0448, United States;
3.State Key Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai; 200050, China;
4.Research Center for Bioengineering and Sensing Technology, University of Science and Technology Beijing, Beijing; 100083, China;
5.Department of Bioengineering, University of California San Diego, 9500 Gilman Drive, San Diego; CA; 92093-0418, United States
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GB/T 7714
Chen, Fang,Ma, Ming,Wang, Junxin,et al. Exosome-like silica nanoparticles: A novel ultrasound contrast agent for stem cell imaging[J]. Nanoscale,2017,9(1):402-411.
APA Chen, Fang.,Ma, Ming.,Wang, Junxin.,Wang, Fang.,Chern, Shi-Xiong.,...&Jokerst, Jesse V..(2017).Exosome-like silica nanoparticles: A novel ultrasound contrast agent for stem cell imaging.Nanoscale,9(1),402-411.
MLA Chen, Fang,et al."Exosome-like silica nanoparticles: A novel ultrasound contrast agent for stem cell imaging".Nanoscale 9.1(2017):402-411.
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