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Antiferromagnetic Pyrite as the Tumor Microenvironment-Mediated Nanoplatform for Self-Enhanced Tumor Imaging and Therapy
Tang, Zhongmin1,2; Zhang, Huilin3; Liu, Yanyan3; Ni, Dalong1; Zhang, Hua4; Zhang, Jiawen4; Yao, Zhenwei4; He, Mingyuan3; Shi, Jianlin1,2,3; Bu, Wenbo1,2,3
2017
发表期刊Advanced Materials
ISSN09359648
卷号29期号:47
摘要Several decades of research have identified the specific tumor microenvironment (TME) to develop promising nanotheranostics, such as pH-sensitive imaging, acidity-sensitive starving therapy, and hydrogen peroxide-activated chemotherapy, etc. Herein, a novel TME-mediated nanoplatform employing antiferromagnetic pyrite nanocubes is presented, exploiting the intratumoral, overproduced peroxide for self-enhanced magnetic resonance imaging (MRI) and photothermal therapy (PTT)/chemodynamic therapy (CDT). Through the activation of excessive peroxide in the tumor microenvironment, pyrite can lead to in situ surface oxidation and generate hydroxyl radicals to kill tumor cells (i.e., CDT). The increase of the valence state of surface Fe significantly promotes the performance of MRI accompanied by CDT. Furthermore, the localized heat by photothermal treatment can accelerate the intratumoral Fenton process, enabling a synergetic PTT/CDT. To our best knowledge, this is the first study to use the TME-response valence-variable strategy based on pyrite for developing a synergetic nanotheranostic, which will open up a new dimension for the design of other TME-based anticancer strategies. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
DOI10.1002/adma.201701683
EI入藏号20175104552262
EI主题词Magnetic resonance imaging
EI分类号461.2 Biological Materials and Tissue Engineering - 461.6 Medicine and Pharmacology - 701.2 Magnetism: Basic Concepts and Phenomena - 802.2 Chemical Reactions
引用统计
被引频次:27[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.sic.ac.cn/handle/331005/25534
专题中国科学院上海硅酸盐研究所
作者单位1.State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai; 200050, China;
2.Shanghai Institute of Ceramics, University of Chinese Academy of Sciences, Beijing; 100049, China;
3.Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai; 200062, China;
4.Department of Radiology, Huashan Hospital, Fudan University, Shanghai; 200040, China
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GB/T 7714
Tang, Zhongmin,Zhang, Huilin,Liu, Yanyan,et al. Antiferromagnetic Pyrite as the Tumor Microenvironment-Mediated Nanoplatform for Self-Enhanced Tumor Imaging and Therapy[J]. Advanced Materials,2017,29(47).
APA Tang, Zhongmin.,Zhang, Huilin.,Liu, Yanyan.,Ni, Dalong.,Zhang, Hua.,...&Bu, Wenbo.(2017).Antiferromagnetic Pyrite as the Tumor Microenvironment-Mediated Nanoplatform for Self-Enhanced Tumor Imaging and Therapy.Advanced Materials,29(47).
MLA Tang, Zhongmin,et al."Antiferromagnetic Pyrite as the Tumor Microenvironment-Mediated Nanoplatform for Self-Enhanced Tumor Imaging and Therapy".Advanced Materials 29.47(2017).
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