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A novel composite scaffold comprising ultralong hydroxyapatite microtubes and chitosan: Preparation and application in drug delivery
Zhang, Yong-Gang1,2; Zhu, Ying-Jie1,2; Chen, Feng1; Sun, Tuan-Wei1,2
2017
Source PublicationJournal of Materials Chemistry B
ISSN20507518
Volume5Issue:21Pages:3898-3906
AbstractIn this work, a novel ultralong hydroxyapatite microtube (HMT)-chitosan (CHS) composite scaffold has been successfully prepared. The mechanical properties of the HMT-CHS composite scaffold is greatly improved compared with the CHS-hydroxyapatite nanorod scaffold and the pure chitosan scaffold. By using gentamicin sulfate (GS) as the model drug, the GS-loaded HMT-CHS composite scaffold has a high drug loading capacity, sustained drug release behavior and high antibacterial activity. The as-prepared HMT-CHS composite scaffold has promising applications in various fields such as drug delivery and bone defect repair. © 2017 The Royal Society of Chemistry.
DOI10.1039/c6tb02576e
EI Accession Number20172803925666
EI KeywordsControlled drug delivery
EI Classification Number405.1 Construction Equipment - 761 Nanotechnology - 804.1 Organic Compounds - 804.2 Inorganic Compounds - 933 Solid State Physics
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Cited Times:7[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sic.ac.cn/handle/331005/25510
Collection中国科学院上海硅酸盐研究所
Affiliation1.State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai; 200050, China;
2.University of Chinese Academy of Sciences, Beijing; 100049, China
Recommended Citation
GB/T 7714
Zhang, Yong-Gang,Zhu, Ying-Jie,Chen, Feng,et al. A novel composite scaffold comprising ultralong hydroxyapatite microtubes and chitosan: Preparation and application in drug delivery[J]. Journal of Materials Chemistry B,2017,5(21):3898-3906.
APA Zhang, Yong-Gang,Zhu, Ying-Jie,Chen, Feng,&Sun, Tuan-Wei.(2017).A novel composite scaffold comprising ultralong hydroxyapatite microtubes and chitosan: Preparation and application in drug delivery.Journal of Materials Chemistry B,5(21),3898-3906.
MLA Zhang, Yong-Gang,et al."A novel composite scaffold comprising ultralong hydroxyapatite microtubes and chitosan: Preparation and application in drug delivery".Journal of Materials Chemistry B 5.21(2017):3898-3906.
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