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Ultralong Hydroxyapatite Nanowires-Based Paper Co-Loaded with Silver Nanoparticles and Antibiotic for Long-Term Antibacterial Benefit
Xiong, Zhi-Chao1; Yang, Zi-Yue2; Zhu, Ying-Jie1; Chen, Fei-Fei1; Zhang, Yong-Gang1; Yang, Ri-Long1
2017
Source PublicationACS Applied Materials and Interfaces
ISSN19448244
Volume9Issue:27Pages:22212-22222
AbstractHydroxyapatite is a kind of biocompatible, environmentally friendly, and versatile inorganic biomaterial. Herein, the preparation of ultralong hydroxyapatite nanowires (HAPNWs)-based antibacterial paper co-loaded with silver nanoparticles (AgNPs) and antibiotic is reported. HAPNWs are used to prepare AgNPs in situ using an aqueous solution containing AgNO3under the sunlight without added reducing agent at room temperature. Subsequently, ciprofloxacin (CIP) as an antibiotic is loaded on the HAPNWs@AgNPs. The resultant HAPNWs@AgNPs-CIP paper possesses several unique properties, including high flexibility, high Brunauer-Emmett-Teller (BET) specific surface area (47.9 m2g-1), high drug loading capacity (447.4 mg g-1), good biocompatibility, sustained and pH-responsive drug release behavior (5.40-6.75% of Ag+ions and 37.7-76.4% of CIP molecules at pH values of 7.4-4.5 at day 8, respectively), and reusable recycling. In the antibacterial tests against Escherichia coli and Staphylococcus aureus, the HAPNWs@AgNPs-CIP paper exhibits large diameters of inhibition zones and low minimum inhibitory concentrations (30 and 40 μg mL-1), revealing the high antibacterial activity. Besides, the consecutive agar diffusion tests (8 cycles), long-term stability tests (over 56 days), and continuous contamination tests (5 cycles) demonstrate the excellent recycling performance and long-term antibacterial activity of the HAPNWs@AgNPs-CIP paper. These results indicate a promising potential of the HAPNWs@AgNPs-CIP bactericidal paper for tackling public health issues related to bacterial infections. © 2017 American Chemical Society.
DOI10.1021/acsami.7b05208
EI Accession Number20172903958123
EI KeywordsSilver compounds
EI Classification Number452.3 Industrial Wastes - 461.6 Medicine and Pharmacology - 461.9.1 Immunology - 761 Nanotechnology - 804.2 Inorganic Compounds - 811.1 Pulp and Paper
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Cited Times:16[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sic.ac.cn/handle/331005/25502
Collection中国科学院上海硅酸盐研究所
Affiliation1.State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai; 200050, China;
2.Sino-German College of Technology, East China University of Science and Technology, Shanghai; 200237, China
Recommended Citation
GB/T 7714
Xiong, Zhi-Chao,Yang, Zi-Yue,Zhu, Ying-Jie,et al. Ultralong Hydroxyapatite Nanowires-Based Paper Co-Loaded with Silver Nanoparticles and Antibiotic for Long-Term Antibacterial Benefit[J]. ACS Applied Materials and Interfaces,2017,9(27):22212-22222.
APA Xiong, Zhi-Chao,Yang, Zi-Yue,Zhu, Ying-Jie,Chen, Fei-Fei,Zhang, Yong-Gang,&Yang, Ri-Long.(2017).Ultralong Hydroxyapatite Nanowires-Based Paper Co-Loaded with Silver Nanoparticles and Antibiotic for Long-Term Antibacterial Benefit.ACS Applied Materials and Interfaces,9(27),22212-22222.
MLA Xiong, Zhi-Chao,et al."Ultralong Hydroxyapatite Nanowires-Based Paper Co-Loaded with Silver Nanoparticles and Antibiotic for Long-Term Antibacterial Benefit".ACS Applied Materials and Interfaces 9.27(2017):22212-22222.
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