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Strontium-doped amorphous calcium phosphate porous microspheres synthesized through a microwave-hydrothermal method using fructose 1,6-bisphosphate as an organic phosphorus source: Application in drug delivery and enhanced bone regeneration
Yu, Weilin1; Sun, Tuan-Wei3,4; Qi, Chao3,4; Ding, Zhenyu1; Zhao, Huakun1; Chen, Feng3,4; Chen, Daoyun1; Zhu, Ying-Jie3,4; Shi, Zhongmin1; He, Yaohua1,2
2017
发表期刊ACS Applied Materials and Interfaces
ISSN19448244
卷号9期号:4页码:3306-3317
摘要Nanostructured calcium phosphate porous microspheres are of great potential in drug delivery and bone regeneration due to their large specific surface area, biocompatibility, and similarity to inorganic component of osseous tissue. In this work, strontium (Sr)-doped amorphous calcium phosphate porous microspheres (SrAPMs) were synthesized through a microwave-hydrothermal method using fructose 1,6-bisphosphate trisodium salt as the source of phosphate ions. The SrAPMs showed a mesoporous structure and a relatively high specific area. Compared with the hydroxyapatite nanorods prepared by using Na2HPO4·12H2O as the phosphorus source, the SrAPMs with a higher specific surface area were more effective in drug loading using vancomycin as the antiobiotics of choice and consequently having a higher antibacterial efficiency both on agar plates and in broths. Furthermore, to assess the potential application of SrAPMs in bone defect repair, a novel biomimetic bone tissue-engineering scaffold consisting of collagen (Coll) and SrAPMs was constructed using a freeze-drying fabrication process. Incorporation of the SrAPMs not only improved the mechanical properties, but also enhanced the osteogenesis of rat bone marrow mesenchymal stem cells. The in vivo experiments demonstrated that the SrAPMs/Coll scaffolds remarkably enhanced new bone formation compared with the Coll and APMs/Coll scaffolds in a rat critical-sized calvarial defect model at 8 weeks postimplantation. In summary, SrAPMs developed in this work are promising as antibiotic carriers and may encourage bone formation when combined with collagen. © 2017 American Chemical Society.
DOI10.1021/acsami.6b12325
EI入藏号20170603334818
EI主题词Strontium compounds
EI分类号405.1 Construction Equipment - 461 Bioengineering and Biology - 761 Nanotechnology - 804 Chemical Products Generally - 933 Solid State Physics
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文献类型期刊论文
条目标识符http://ir.sic.ac.cn/handle/331005/25487
专题中国科学院上海硅酸盐研究所
作者单位1.Department of Orthopedics, Shanghai Jiaoong University, Affiliated Sixth Peoples Hospital, 600 Yishan Road, Shanghai; 200233, China;
2.School of Biomedical Engineering, Shanghai Jiaoong University, Affiliated Sixth Peoples Hospital, 600 Yishan Road, Shanghai; 200233, China;
3.State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Dingxi Road, Shanghai; 200050, China;
4.University of Chinese, Academy of Sciences, 19 Yuquan Road, Beijing; 100049, China
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Yu, Weilin,Sun, Tuan-Wei,Qi, Chao,et al. Strontium-doped amorphous calcium phosphate porous microspheres synthesized through a microwave-hydrothermal method using fructose 1,6-bisphosphate as an organic phosphorus source: Application in drug delivery and enhanced bone regeneration[J]. ACS Applied Materials and Interfaces,2017,9(4):3306-3317.
APA Yu, Weilin.,Sun, Tuan-Wei.,Qi, Chao.,Ding, Zhenyu.,Zhao, Huakun.,...&He, Yaohua.(2017).Strontium-doped amorphous calcium phosphate porous microspheres synthesized through a microwave-hydrothermal method using fructose 1,6-bisphosphate as an organic phosphorus source: Application in drug delivery and enhanced bone regeneration.ACS Applied Materials and Interfaces,9(4),3306-3317.
MLA Yu, Weilin,et al."Strontium-doped amorphous calcium phosphate porous microspheres synthesized through a microwave-hydrothermal method using fructose 1,6-bisphosphate as an organic phosphorus source: Application in drug delivery and enhanced bone regeneration".ACS Applied Materials and Interfaces 9.4(2017):3306-3317.
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