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Two-Dimensional Graphene Augments Nanosonosensitized Sonocatalytic Tumor Eradication
Dai, Chen1,3; Zhang, Shengjian2; Liu, Zhuang2; Wu, Rong1; Chen, Yu4
2017
发表期刊ACS Nano
ISSN19360851
卷号11期号:9页码:9467-9480
摘要Ultrasound (US) can activate sonosensitizers for sonodynamic therapy (SDT), but the low activation efficiency and therapeutic outcome significantly hinder its further clinical translation. Inspired by the principles of semiconductor physics and photocatalysis chemistry, we herein report on augmenting the sonocatalytic efficiency of semiconductor TiO2-based nanosonosensitizers for highly efficient SDT by the integration of two-dimensional (2D) ultrathin graphene with TiO2nanosonosensitizers. The high electroconductivity of graphene facilitates the separation of the electron (e-) and hole (h+) pairs from the energy band of TiO2and avoids their recombination upon external US irradiation; thus it significantly augments the therapeutic efficiency of TiO2nanosonosensitizers for SDT against tumors. By further MnOxfunctionalization, these 2D composite nanosonosensitizers achieved tumor microenvironment-sensitive (mild acidity) T1-weighted magnetic resonance imaging of tumors for therapeutic guidance and monitoring. The high photothermal-conversion capability of graphene also synergistically enhanced the SDT efficiency, achieving the complete eradication of a tumor without reoccurrence. This work provides a paradigm for augmenting semiconductor TiO2-based sonocatalytic therapeutic nanomedicine by learning the physiochemical principles from traditional photocatalysis, which also demonstrates a highly efficient noninvasive and safe therapeutic modality for tumor eradication by the nanosonosensitized sonocatalytic process. © 2017 American Chemical Society.
DOI10.1021/acsnano.7b05215
EI入藏号20174004220843
EI主题词Graphene
EI分类号461.2 Biological Materials and Tissue Engineering - 708.4 Magnetic Materials - 741.1 Light/Optics - 746 Imaging Techniques - 761 Nanotechnology - 804 Chemical Products Generally - 804.2 Inorganic Compounds
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文献类型期刊论文
条目标识符http://ir.sic.ac.cn/handle/331005/25438
专题中国科学院上海硅酸盐研究所
作者单位1.Department of Ultrasound in Medicine, Shanghai Tenth People's Hospital, Tongji University, School of Medicine, Shanghai; 200072, China;
2.Department of Radiology, Fudan University Shanghai Cancer Center, Shanghai; 200032, China;
3.Department of Ultrasound, Shanghai East Hospital, Tongji University, School of Medicine, Shanghai; 200120, China;
4.State Key Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai; 200050, China
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Dai, Chen,Zhang, Shengjian,Liu, Zhuang,et al. Two-Dimensional Graphene Augments Nanosonosensitized Sonocatalytic Tumor Eradication[J]. ACS Nano,2017,11(9):9467-9480.
APA Dai, Chen,Zhang, Shengjian,Liu, Zhuang,Wu, Rong,&Chen, Yu.(2017).Two-Dimensional Graphene Augments Nanosonosensitized Sonocatalytic Tumor Eradication.ACS Nano,11(9),9467-9480.
MLA Dai, Chen,et al."Two-Dimensional Graphene Augments Nanosonosensitized Sonocatalytic Tumor Eradication".ACS Nano 11.9(2017):9467-9480.
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