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Europium-doped mesoporous silica nanosphere as an immune-modulating osteogenesis/angiogenesis agent
Shi, Mengchao1,2; Xia, Lunguo3; Chen, Zetao4; Lv, Fang5; Zhu, Huiying1; Wei, Fei4; Han, Shengwei4; Chang, Jiang1,2; Xiao, Yin2,4; Wu, Chengtie1,2
2017
Source PublicationBiomaterials
ISSN01429612
Volume144Pages:176-187
AbstractAlthough much research has gone into the design of nanomaterials, inflammatory response still impedes the capacity of nanomaterial-induced tissue regeneration. In-situ incorporation of nutrient elements in silica-based biomaterials has emerged as a new option to endow the nanomaterials modulating biological reactions. In this work, europium-doped mesoporous silica nanospheres (Eu-MSNs) were successfully synthesized via a one-pot method. The nanospheres (size of 280–300 nm) possess uniformly spherical morphology and mesoporous structure, and well distributed Eu elements. The nanospheres show distinct fluorescent property at 615 nm for potential bio-labeling. Noticeably, the Eu-MSNs stimulate pro-inflammatory response of macrophages and induce a modulated immune microenvironment, which further activates the osteogenic differentiation of bone marrow stromal cells (BMSCs) as well as angiogenic activity of human umbilical vein endothelial cells (HUVECs). During the process, osteogenesis-related genes (e.g. ALP, OCN, OPN and COL-I) of BMSCs, and angiogenesis-related genes (e.g. CD31, MMP9, VEGFR1/2, and PDGFRα/β) of HUVECs were significantly upregulated by Eu-MSNs modulating immune environment of macrophages. The in vivo study further demonstrated that the Eu-MSNs could not only stimulate osteogenesis by accelerating the new bone formation at critical-sized cranial defect site, but also support the blood vessel formation as well as collagen deposition and re-epithelialization at chronic skin wound sites, showing an improved angiogenesis activity when comparing with MSNs alone. Given the easy handling characteristics and extensive application potential, the results suggest that Eu-MSNs could be used as immunity-modulated osteogenesis/angiogenesis agent for skin and bone regeneration. © 2017 Elsevier Ltd
DOI10.1016/j.biomaterials.2017.08.027
EI Accession Number20173404068682
EI KeywordsTissue regeneration
EI Classification Number461 Bioengineering and Biology - 547.2 Rare Earth Metals - 761 Nanotechnology - 933 Solid State Physics
Citation statistics
Cited Times:18[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sic.ac.cn/handle/331005/25420
Collection中国科学院上海硅酸盐研究所
Affiliation1.State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai; 200050, China;
2.Australia – China Centre for Tissue Engineering and Regenerative Medicine, Queensland University of Technology, Brisbane; Queensland; 4059, Australia;
3.Center of Craniofacial Orthodontics, Department of Oral and Cranio-maxillofacial Science, Ninth People's Hospital Affiliated to Shanghai Jiao Tong University, School of Medicine, Shanghai; 200011, China;
4.Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane; Queensland; 4059, Australia;
5.Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai; 200241, China
Recommended Citation
GB/T 7714
Shi, Mengchao,Xia, Lunguo,Chen, Zetao,et al. Europium-doped mesoporous silica nanosphere as an immune-modulating osteogenesis/angiogenesis agent[J]. Biomaterials,2017,144:176-187.
APA Shi, Mengchao.,Xia, Lunguo.,Chen, Zetao.,Lv, Fang.,Zhu, Huiying.,...&Wu, Chengtie.(2017).Europium-doped mesoporous silica nanosphere as an immune-modulating osteogenesis/angiogenesis agent.Biomaterials,144,176-187.
MLA Shi, Mengchao,et al."Europium-doped mesoporous silica nanosphere as an immune-modulating osteogenesis/angiogenesis agent".Biomaterials 144(2017):176-187.
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