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Sonochemical synthesis of fructose 1,6-bisphosphate dicalcium porous microspheres and their application in promotion of osteogenic differentiation
Qi, Chao1; Zhou, Ding2; Zhu, Ying-Jie1; Sun, Tuan-Wei1; Chen, Feng1; Zhang, Chang-Qing2
2017
Source PublicationMaterials Science and Engineering C
ISSN09284931
Volume77Pages:846-856
AbstractHuman bone mesenchymal stem cells (hBMSCs) have the ability to differentiate into bone and cartilage for clinical bone regeneration. Biomaterials with an innate ability to stimulate osteogenic differentiation of hBMSCs into bone and cartilage are considered attractive candidates for the applications in bone tissue engineering and regeneration. In this paper, we synthesized fructose 1,6-bisphosphate dicalcium (Ca2FBP) porous microspheres by the sonochemical method, and investigated the ability of Ca2FBP for the promotion of the osteogenic differentiation of hBMSCs. After the hBMSCs were co-cultured with the sterilized powder of Ca2FBP porous microspheres for different times, the cell proliferation assay, alkaline phosphatase activity assay, quantitative real-time polymerase chain reaction and western blotting were performed to investigate the bioactivity and osteogenic differentiation performance of the as-prepared product. Compared with hydroxyapatite nanorods, Ca2FBP porous microspheres show a superior bioactivity and osteoinductive potential, and can promote the cell differentiation of hBMSCs in vitro, thus, they are promising for applications in the tissue engineering field such as dental and bone defect repair. © 2016 Elsevier B.V.
DOI10.1016/j.msec.2017.03.297
EI Accession Number20171503556209
EI KeywordsBoron compounds
EI Classification Number461 Bioengineering and Biology - 761 Nanotechnology - 801.1 Chemistry, General - 801.2 Biochemistry - 804 Chemical Products Generally - 933 Solid State Physics
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Document Type期刊论文
Identifierhttp://ir.sic.ac.cn/handle/331005/25419
Collection中国科学院上海硅酸盐研究所
Affiliation1.State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai; 200050, China;
2.Department of Orthopedic Surgery, Shanghai Sixth People's Hospital, Shanghai Jiaotong University, Shanghai; 200233, China
Recommended Citation
GB/T 7714
Qi, Chao,Zhou, Ding,Zhu, Ying-Jie,et al. Sonochemical synthesis of fructose 1,6-bisphosphate dicalcium porous microspheres and their application in promotion of osteogenic differentiation[J]. Materials Science and Engineering C,2017,77:846-856.
APA Qi, Chao,Zhou, Ding,Zhu, Ying-Jie,Sun, Tuan-Wei,Chen, Feng,&Zhang, Chang-Qing.(2017).Sonochemical synthesis of fructose 1,6-bisphosphate dicalcium porous microspheres and their application in promotion of osteogenic differentiation.Materials Science and Engineering C,77,846-856.
MLA Qi, Chao,et al."Sonochemical synthesis of fructose 1,6-bisphosphate dicalcium porous microspheres and their application in promotion of osteogenic differentiation".Materials Science and Engineering C 77(2017):846-856.
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