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Oxygen Vacancy Enables Markedly Enhanced Magnetic Resonance Imaging-Guided Photothermal Therapy of a Gd3+-Doped Contrast Agent
Ni, Dalong1,2,3; Zhang, Jiawen4; Wang, Jing4; Hu, Ping1; Jin, Yingying4; Tang, Zhongmin1,2; Yao, Zhenwei4; Bu, Wenbo1,3; Shi, Jianlin1
2017
发表期刊ACS Nano
ISSN19360851
卷号11期号:4页码:4256-4264
摘要Gd3+-based contrast agents (CAs) are the most prevailing and widely used for enhanced magnetic resonance imaging (MRI). Numbers of approaches have been developed to regulate the key parameters in order to obtain high-relaxivity CAs, according to the classic Solomon-Bloembergen-Morgen theory. Herein, a method of controlling oxygen vacancies in inorganic nanosized CAs has been developed for largely accelerated proton relaxation to obtain a high r1value. Such a strategy is verified on oxygen-deficient PEG-NaxGdWO3nanorods, which exhibit a remarkable r1value up to 80 mM-1s-1(at 0.7 T) and a high r1value of 32.1 mM-1s-1on a clinical 3.0 T scanner, offering an excellent blood pool MRI performance at a low dose. Meanwhile, free electrons and/or oxygen-vacancy-induced small polarons can endow PEG-NaxGdWO3nanorods with significant photothermal conversion for MRI-guided photothermal therapy. © 2017 American Chemical Society.
DOI10.1021/acsnano.7b01297
EI入藏号20171703607911
EI主题词Oxygen vacancies
EI分类号544.2 Copper Alloys - 701.2 Magnetism: Basic Concepts and Phenomena - 761 Nanotechnology - 931.1 Mechanics - 933 Solid State Physics - 933.1 Crystalline Solids
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被引频次:20[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.sic.ac.cn/handle/331005/25417
专题中国科学院上海硅酸盐研究所
作者单位1.State Key Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai; 200050, China;
2.University of Chinese Academy of Science, Beijing; 100049, China;
3.Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai; 200062, China;
4.Department of Radiology, Huashan Hospital, Fudan University, Shanghai; 200040, China
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Ni, Dalong,Zhang, Jiawen,Wang, Jing,et al. Oxygen Vacancy Enables Markedly Enhanced Magnetic Resonance Imaging-Guided Photothermal Therapy of a Gd3+-Doped Contrast Agent[J]. ACS Nano,2017,11(4):4256-4264.
APA Ni, Dalong.,Zhang, Jiawen.,Wang, Jing.,Hu, Ping.,Jin, Yingying.,...&Shi, Jianlin.(2017).Oxygen Vacancy Enables Markedly Enhanced Magnetic Resonance Imaging-Guided Photothermal Therapy of a Gd3+-Doped Contrast Agent.ACS Nano,11(4),4256-4264.
MLA Ni, Dalong,et al."Oxygen Vacancy Enables Markedly Enhanced Magnetic Resonance Imaging-Guided Photothermal Therapy of a Gd3+-Doped Contrast Agent".ACS Nano 11.4(2017):4256-4264.
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