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Core-shell hierarchical mesostructured silica nanoparticles for gene/chemo-synergetic stepwise therapy of multidrug-resistant cancer
Sun, Lijun1,3; Wang, Dangge2; Chen, Yu1; Wang, Liying1,3; Huang, Ping1; Li, Yaping2; Liu, Ziwei1; Yao, Heliang1; Shi, Jianlin1
2017
Source PublicationBiomaterials
ISSN01429612
Volume133Pages:219-228
AbstractThe design and synthesis of hierarchically nanoporous structures for the co-encapsulation and sequential releases of different cargos are still great challenges in biomedical applications. In this work, we report on the elaborate design and controlled synthesis of a unique core-shell hierarchical mesoporous silica/organosilica nanosystem, in which there are large and small mesopores separately present in the shell and core, facilitating the independent encapsulations of large (siRNA) and small (doxorubicin) molecules, respectively. Importantly, the framework of the organosilica shell is molecularly hybridized with disulfide bonds, which enables the unique responsiveness to the reductive tumor microenvironment for the controlled releasing of loaded gene molecules, followed by the subsequent doxorubicin release. The first released large siRNA molecules from the organosilica shell down-regulated the expression of P-gp in the cell membrane and reversed the MDR of cancer cells, thus enhancing the antitumor effect of subsequently released small DOX molecules from the silica core, and in such a synergetic way the MDR tumor growth can be efficiently inhibited. This work shows the significant advantages compared to the traditional small-mesoporous or large-mesoporous nanosystems for drug co-delivery. © 2017 Elsevier Ltd
DOI10.1016/j.biomaterials.2017.04.028
EI Accession Number20171703601433
EI KeywordsControlled drug delivery
EI Classification Number408.2 Structural Members and Shapes - 461.2 Biological Materials and Tissue Engineering - 461.8.1 Genetic Engineering - 761 Nanotechnology - 801.4 Physical Chemistry - 802.2 Chemical Reactions - 931.3 Atomic and Molecular Physics - 933 Solid State Physics
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Document Type期刊论文
Identifierhttp://ir.sic.ac.cn/handle/331005/25406
Collection中国科学院上海硅酸盐研究所
Affiliation1.State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Ding-Xi Road, Shanghai; 200050, China;
2.Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Shanghai; 201203, China;
3.University of Chinese Academy of Sciences, Beijing; 100049, China
Recommended Citation
GB/T 7714
Sun, Lijun,Wang, Dangge,Chen, Yu,et al. Core-shell hierarchical mesostructured silica nanoparticles for gene/chemo-synergetic stepwise therapy of multidrug-resistant cancer[J]. Biomaterials,2017,133:219-228.
APA Sun, Lijun.,Wang, Dangge.,Chen, Yu.,Wang, Liying.,Huang, Ping.,...&Shi, Jianlin.(2017).Core-shell hierarchical mesostructured silica nanoparticles for gene/chemo-synergetic stepwise therapy of multidrug-resistant cancer.Biomaterials,133,219-228.
MLA Sun, Lijun,et al."Core-shell hierarchical mesostructured silica nanoparticles for gene/chemo-synergetic stepwise therapy of multidrug-resistant cancer".Biomaterials 133(2017):219-228.
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