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The synergistic effect of type i collagen and hyaluronic acid on the biological properties of Col/HA-multilayer-modified titanium coatings: An in vitro and in vivo study
Ao, Haiyong1,2; Lin, Chucheng3; Nie, Binen4; Yang, Shengbing4; Xie, Youtao2; Wan, Yizao1; Zheng, Xuebin2
2017
Source PublicationRSC Advances
Volume7Issue:42Pages:25828-25837
AbstractType I collagen and hyaluronic acid are both the main components of bone extracellular matrix, and play important roles in regulating a cell's behavior. In this study, the synergistic effects of type I collagen (Col) and hyaluronic acid (HA) on the biological properties of Col/HA-multilayer-modified titanium coatings were investigated. In vitro, the results of human mesenchymal stem cells culture indicated that Col/HA-multilayers-modified titanium coatings (TC-AA(C/H)6) could better improve a cell's adhesion, proliferation, and differentiation, compared with collagen-modified titanium coatings (TC-AAC) and hyaluronic acid-modified titanium coatings (TC-AAH). In vivo, the micro-CT images indicated that bone trabecula around TC-AA(C/H)6were significantly more than with TC-AAC and TC-AAH. The fluorescence micrograph showed more active new bone formation around implants in TC-AA(C/H)6group than in the TC-AAC and TC-AAH groups in the first month. Measurement of the bone-implant contact on the histological sections indicated there was significantly good osteointegration around TC-AA(C/H)6implants than with the other two modified titanium coatings. All of these results demonstrated that there exists favorable synergistic effects of type I collagen and hyaluronic acid. © 2017 The Royal Society of Chemistry.
DOI10.1039/c6ra27364e
EI Accession Number20172703890410
EI KeywordsHyaluronic acid
EI Classification Number461.2 Biological Materials and Tissue Engineering - 542.3 Titanium and Alloys - 723.5 Computer Applications - 804.1 Organic Compounds - 813.2 Coating Materials
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Document Type期刊论文
Identifierhttp://ir.sic.ac.cn/handle/331005/25405
Collection中国科学院上海硅酸盐研究所
Affiliation1.School of Materials Science and Engineering, East China Jiaotong University, Nanchang; 330013, China;
2.Key Laboratory of Inorganic Coating Materials, Shanghai Institute of Ceramics, Chinese Academy of Science, Shanghai; 200050, China;
3.State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai; 200050, China;
4.Shanghai Key Laboratory of Orthopedic Implants, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai; 200011, China
Recommended Citation
GB/T 7714
Ao, Haiyong,Lin, Chucheng,Nie, Binen,et al. The synergistic effect of type i collagen and hyaluronic acid on the biological properties of Col/HA-multilayer-modified titanium coatings: An in vitro and in vivo study[J]. RSC Advances,2017,7(42):25828-25837.
APA Ao, Haiyong.,Lin, Chucheng.,Nie, Binen.,Yang, Shengbing.,Xie, Youtao.,...&Zheng, Xuebin.(2017).The synergistic effect of type i collagen and hyaluronic acid on the biological properties of Col/HA-multilayer-modified titanium coatings: An in vitro and in vivo study.RSC Advances,7(42),25828-25837.
MLA Ao, Haiyong,et al."The synergistic effect of type i collagen and hyaluronic acid on the biological properties of Col/HA-multilayer-modified titanium coatings: An in vitro and in vivo study".RSC Advances 7.42(2017):25828-25837.
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