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Near-Infrared-Activated Upconversion Nanoprobes for Sensitive Endogenous Zn2+Detection and Selective On-Demand Photodynamic Therapy
Hu, Ping1,2; Wang, Rui1; Zhou, Lei1; Chen, Lei1; Wu, Qingsheng3; Han, Ming-Yong4; El-Toni, Ahmed Mohamed5; Zhao, Dongyuan1; Zhang, Fan1
2017
Source PublicationAnalytical Chemistry
ISSN00032700
Volume89Issue:6Pages:3492-3500
AbstractAs a light-activated noninvasive cancer treatment paradigm, photodynamic therapy (PDT) has attracted extensive attention because of its high treatment efficacy and low side effects. Especially, spatiotemporal control of singlet oxygen (1O2) release is highly desirable for realizing on-demand PDT, which, however, still remains a huge challenge. To address this issue, a novel switchable near-infrared (NIR)-responsive upconversion nanoprobe has been designed and successfully applied for controlled PDT that can be optically activated by tumor-associated disruption of labile Zn2+(denoted as Zn2+hereafter) homeostasis stimuli. Upon NIR irradiation, this theranostic probe can not only quantitatively detect the intracellular endogenous Zn2+in situ but also selectively generate a great deal of cytotoxic reactive oxygen species (ROS) for efficiently killing breast cancer cells under the activation of excessive endogenous Zn2+, so as to maximally avoid adverse damage to normal cells. This study aims to propose a new tumor-specific PDT paradigm and, more importantly, provide a new avenue of thought for efficient cancer theranostics based on our designed highly sensitive upconversion nanoprobes. (Figure Presented). © 2017 American Chemical Society.
DOI10.1021/acs.analchem.6b04548
EI Accession Number20171903645126
EI KeywordsPhotodynamic therapy
EI Classification Number461.2 Biological Materials and Tissue Engineering - 461.6 Medicine and Pharmacology - 761 Nanotechnology - 804 Chemical Products Generally - 933 Solid State Physics
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Cited Times:18[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sic.ac.cn/handle/331005/25385
Collection中国科学院上海硅酸盐研究所
Affiliation1.Department of Chemistry, Collaborative Innovation Center of Chemistry for Energy Materials, State Key Laboratory of Molecular Engineering of Polymers, Fudan University, Shanghai; 200433, China;
2.State Key Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai; 200050, China;
3.Department of Chemistry, Tongji University, Shanghai; 200092, China;
4.Institute of Materials Research and Engineering, 2 Fusionopolis Way, Singapore; 138634, Singapore;
5.King Abdullah Institute for Nanotechnology, King Saud University, Riyadh; 11451, Saudi Arabia
Recommended Citation
GB/T 7714
Hu, Ping,Wang, Rui,Zhou, Lei,et al. Near-Infrared-Activated Upconversion Nanoprobes for Sensitive Endogenous Zn2+Detection and Selective On-Demand Photodynamic Therapy[J]. Analytical Chemistry,2017,89(6):3492-3500.
APA Hu, Ping.,Wang, Rui.,Zhou, Lei.,Chen, Lei.,Wu, Qingsheng.,...&Zhang, Fan.(2017).Near-Infrared-Activated Upconversion Nanoprobes for Sensitive Endogenous Zn2+Detection and Selective On-Demand Photodynamic Therapy.Analytical Chemistry,89(6),3492-3500.
MLA Hu, Ping,et al."Near-Infrared-Activated Upconversion Nanoprobes for Sensitive Endogenous Zn2+Detection and Selective On-Demand Photodynamic Therapy".Analytical Chemistry 89.6(2017):3492-3500.
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