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M2 macrophages contribute to osteogenesis and angiogenesis on nanotubular TiO2surfaces
Wang, Jie1,2; Qian, Shi3; Liu, Xuanyong3; Xu, Lianyi1,2; Miao, Xinchao1,2; Xu, Zhenyao4; Cao, Lingyan1,2; Wang, Honglin4; Jiang, Xinquan1,2
2017
Source PublicationJournal of Materials Chemistry B
ISSN20507518
Volume5Issue:18Pages:3364-3376
AbstractThe monocyte/macrophage system plays an essential role in the host response and the fate of endosseous implanted materials. Macrophage behavior was thought to be regulated by nanostructured titanium which has been considered as a very promising candidate for dental implants. However, there is little known for subsequent effects of these activated macrophages on osteogenesis and angiogenesis which were essential for bone integration. Here we presented two different dimensions of titanium nanotubes generated by anodic oxidation at 10 V (NT 10) and 20 V (NT 20), respectively. The behavior of macrophages on the surfaces was evaluated, and their conditioned medium (CM) was collected to stimulate MC3T3 and HUVECs, with commercially pure titanium (cp Ti) as control. We found that NT 20 induced macrophage activation similar to the anti-inflammatory M2 macrophage state with the enhanced expression of IL-10 and ARG, while NT 10 was associated with M1 macrophage phenotype characterized by high levels of IL-1β, iNOS and TNF-α. Furthermore, the osteogenic capacity of MC3T3 in CM from NT 20 was enhanced (NT 20 > NT 10 ≈ cp Ti) and the tube formation capacity of HUVECs was promoted in CM from nanotubular surfaces with increasing tube dimensions (NT 20 > NT 10 > cp Ti). Our data suggest that dental implants with the large nanotube dimension surface could result in a favorable osteoimmunomodulatory microenvironment for the establishment of osseointegration. © The Royal Society of Chemistry 2017.
DOI10.1039/c6tb03364d
EI Accession Number20172703896080
EI KeywordsMacrophages
EI Classification Number461.9.1 Immunology - 462.3 Dental Equipment and Supplies - 539.2.1 Protection Methods - 542.3 Titanium and Alloys - 761 Nanotechnology - 804.2 Inorganic Compounds - 819.4 Fiber Products
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Document Type期刊论文
Identifierhttp://ir.sic.ac.cn/handle/331005/25377
Collection中国科学院上海硅酸盐研究所
Affiliation1.Department of Prosthodontics, Ninth People's Hospital Affiliated to Shanghai Jiao Tong University, School of Medicine, 639 Zhizaoju Road, Shanghai; 200011, China;
2.Oral Bioengineering Lab, Ninth People's Hospital Affiliated to Shanghai Jiao Tong University, School of Medicine, Shanghai Key Laboratory of Stomatology, 639 Zhizaoju Road, Shanghai; 200011, China;
3.State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai; 200050, China;
4.Shanghai Institute of Immunology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University, School of Medicine, 280 Chongqing South Road, Shanghai; 200025, China
Recommended Citation
GB/T 7714
Wang, Jie,Qian, Shi,Liu, Xuanyong,et al. M2 macrophages contribute to osteogenesis and angiogenesis on nanotubular TiO2surfaces[J]. Journal of Materials Chemistry B,2017,5(18):3364-3376.
APA Wang, Jie.,Qian, Shi.,Liu, Xuanyong.,Xu, Lianyi.,Miao, Xinchao.,...&Jiang, Xinquan.(2017).M2 macrophages contribute to osteogenesis and angiogenesis on nanotubular TiO2surfaces.Journal of Materials Chemistry B,5(18),3364-3376.
MLA Wang, Jie,et al."M2 macrophages contribute to osteogenesis and angiogenesis on nanotubular TiO2surfaces".Journal of Materials Chemistry B 5.18(2017):3364-3376.
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