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Strength, toughness, and reliability of a porous glass/biopolymer composite scaffold
Fu, Qiang1; Jia, Weitao2; Lau, Grace Y.1; Tomsia, Antoni P.1
2018
Source PublicationJournal of Biomedical Materials Research - Part B Applied Biomaterials
ISSN15524973
Volume106Issue:3Pages:1209-1217
AbstractDevelopment of bioactive glass and ceramic scaffolds intended for the reconstruction of large segmental bone defects remains a challenge for materials science due to the complexities involved in clinical implantation, bone–implant reaction, implant degradation and the multiple loading modes the implants subjected to. A comprehensive evaluation of the mechanical properties of inorganic scaffolds and exploration of new ways to toughen brittle constructs are critical prior to their successful application in loaded sites. A simple and widely adopted approach involves the coating of an inorganic scaffold with a polymeric material. In this work, a systematic evaluation of the influence of a biopolymer, polycaprolactone (PCL), coating on the mechanical performance of bioactive glass scaffolds was carried out. Results from this work indicate that a biopolymer PCL coating was more effective in increasing the compressive strength and reliability of the glass scaffold under compression, but less effective in improving its flexural strength or fracture toughness. This is the first report that reveals the limited successfulness of a polymer coating in improving the toughness of strong scaffolds, suggesting that new and novel ways of toughening inorganic scaffolds should be future research directions for scaffolds applied in loaded sites. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 1209–1217, 2018. © 2017 Wiley Periodicals, Inc.
DOI10.1002/jbm.b.33924
PublisherJohn Wiley and Sons Inc., P.O.Box 18667, Newark, NJ 07191-8667, United States
EI KeywordsFracture toughness
EI Classification Number461.2 Biological Materials and Tissue Engineering - 461.9 Biology - 462.5 Biomaterials (including synthetics) - 804.1 Organic Compounds - 813.2 Coating Materials - 815.1 Polymeric Materials - 951 Materials Science
Citation statistics
Cited Times:4[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sic.ac.cn/handle/331005/25340
Collection中国科学院上海硅酸盐研究所
Affiliation1.Materials Sciences Division, Lawrence Berkeley National Laboratory, Berkeley; CA; 94720, United States;
2.Department of Orthopedic Surgery, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai; 200233, China
Recommended Citation
GB/T 7714
Fu, Qiang,Jia, Weitao,Lau, Grace Y.,et al. Strength, toughness, and reliability of a porous glass/biopolymer composite scaffold[J]. Journal of Biomedical Materials Research - Part B Applied Biomaterials,2018,106(3):1209-1217.
APA Fu, Qiang,Jia, Weitao,Lau, Grace Y.,&Tomsia, Antoni P..(2018).Strength, toughness, and reliability of a porous glass/biopolymer composite scaffold.Journal of Biomedical Materials Research - Part B Applied Biomaterials,106(3),1209-1217.
MLA Fu, Qiang,et al."Strength, toughness, and reliability of a porous glass/biopolymer composite scaffold".Journal of Biomedical Materials Research - Part B Applied Biomaterials 106.3(2018):1209-1217.
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