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Simultaneous Blood-Brain Barrier Crossing and Protection for Stroke Treatment Based on Edaravone-Loaded Ceria Nanoparticles
Bao, Qunqun1,2; Hu, Ping; Xu, Yingying2; Cheng, Tiansheng2; Wei, Chenyang; Pan, Limin; Shi, Jianlin
2018
Source PublicationACS NANO
ISSN1936-0851
Volume12Issue:7Pages:6794
AbstractCerebral vasculature and neuronal networks will be largely destroyed due to the oxidative damage by overproduced reactive oxygen species (ROS) during a stroke, accompanied by the symptoms of ischemic injury and blood-brain barrier (BBB) disruption. Ceria nanoparticles, acting as an effective and recyclable ROS scavenger, have been shown to be highly effective in neuroprotection. However, the brain access of nanoparticles can only be achieved by targeting the damaged area of BBB, leading to the disrupted BBB being unprotected and to turbulence of the microenvironment in the brain. Nevertheless, the integrity of the BBB will cause very limited accumulation of therapeutic nanoparticles in brain lesions. This dilemma is a great challenge in the development of efficient stroke nanotherapeutics. Herein, we have developed an effective stroke treatment agent based on monodisperse ceria nanoparticles, which are loaded with edaravone and modified with Angiopep-2 and poly(ethylene glycol) on their surface (E-A/P-CeO2). The as-designed E-A/P-CeO2 features highly effective BBB crossing via receptor-mediated transcytosis to access brain tissues and synergistic elimination of ROS by both the loaded edaravone and ceria nanoparticles. As a result, the E-A/P-CeO2 with low toxicity and excellent hemo/histocompatibility can be used to effectively treat strokes due to great intracephalic uptake enhancement and, in the meantime, effectively protect the BBB, holding great potentials in stroke therapy with much mitigated harmful side effects and sequelae
Keywordstroke blood-brain barrier ceria nanoparticles edaravone reactive oxygen species
Subject AreaChemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
MOST Discipline CatalogueChemistry ; Science & Technology - Other Topics ; Materials Science
Funding OrganizationThis work was financially supported by National Natural Science Foundation of China (Grant Nos. 51502326 and 51702349), Shanghai Yangfan Program (16YF1412800), Youth Innovation Promotion Association Chinese Academy of Sciences (Grant No. 2017299), Science Foundation for Youth Scholar of State Key Laboratory of High Performance Ceramics and Superfine Microstructures (SKL201704). ; This work was financially supported by National Natural Science Foundation of China (Grant Nos. 51502326 and 51702349), Shanghai Yangfan Program (16YF1412800), Youth Innovation Promotion Association Chinese Academy of Sciences (Grant No. 2017299), Science Foundation for Youth Scholar of State Key Laboratory of High Performance Ceramics and Superfine Microstructures (SKL201704).
DOI10.1021/acsnano.8b01994
Funding OrganizationThis work was financially supported by National Natural Science Foundation of China (Grant Nos. 51502326 and 51702349), Shanghai Yangfan Program (16YF1412800), Youth Innovation Promotion Association Chinese Academy of Sciences (Grant No. 2017299), Science Foundation for Youth Scholar of State Key Laboratory of High Performance Ceramics and Superfine Microstructures (SKL201704). ; This work was financially supported by National Natural Science Foundation of China (Grant Nos. 51502326 and 51702349), Shanghai Yangfan Program (16YF1412800), Youth Innovation Promotion Association Chinese Academy of Sciences (Grant No. 2017299), Science Foundation for Youth Scholar of State Key Laboratory of High Performance Ceramics and Superfine Microstructures (SKL201704).
WOS SubjectOXIDE NANOPARTICLES ; SUPEROXIDE-DISMUTASE ; HYDROGEN-PEROXIDE ; DISEASE ; INJURY ; BREAKDOWN ; ISCHEMIA ; DELIVERY ; ANTIOXIDANTS ; SCAVENGER
WOS IDWOS:000440505000044
PublisherAMER CHEMICAL SOC
EI Accession Number1936-086X
Citation statistics
Cited Times:12[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sic.ac.cn/handle/331005/24832
Collection中国科学院上海硅酸盐研究所
Affiliation1.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.ShanghaiTech Univ, Sch Phys Sci & Technol, Shanghai 201210, Peoples R China
Recommended Citation
GB/T 7714
Bao, Qunqun,Hu, Ping,Xu, Yingying,et al. Simultaneous Blood-Brain Barrier Crossing and Protection for Stroke Treatment Based on Edaravone-Loaded Ceria Nanoparticles[J]. ACS NANO,2018,12(7):6794, 6805.
APA Bao, Qunqun.,Hu, Ping.,Xu, Yingying.,Cheng, Tiansheng.,Wei, Chenyang.,...&Shi, Jianlin.(2018).Simultaneous Blood-Brain Barrier Crossing and Protection for Stroke Treatment Based on Edaravone-Loaded Ceria Nanoparticles.ACS NANO,12(7),6794.
MLA Bao, Qunqun,et al."Simultaneous Blood-Brain Barrier Crossing and Protection for Stroke Treatment Based on Edaravone-Loaded Ceria Nanoparticles".ACS NANO 12.7(2018):6794.
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