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Theranostic 2D Tantalum Carbide (MXene)
Lin, Han1; Wang, Youwei; Gao, Shanshan1; Chen, Yu; Shi, Jianlin
2018
Source PublicationADVANCED MATERIALS
ISSN0935-9648
Volume30Issue:4
AbstractThe large-dimensional and rigid ceramic bulks fabricated by high-temperature solid-phase reaction and sintering have never been considered for possibly entering and circulating within the blood vessels for biomedical applications, especially on combating cancer. Here, it is reported for the first time that MAX ceramic biomaterials exhibit unique functionalities for dual-mode photoacoustic/computed tomography imaging and are highly effective for in vivo photothermal ablation of tumors upon being exfoliated into ultrathin nanosheets within atomic thickness (MXene). As a paradigm, 2D ultrathin tantalum carbide nanosheets (Ta4C3 MXenes) with nanosized lateral sizes are successfully synthesized based on a two-step liquid exfoliation strategy of MAX phase Ta4AlC3 by combined hydrofluoric acid (HF) etching and probe sonication. The structural, electronic, and surface characteristics of the as-exfoliated nanosheets are revealed by various characterizations combined with first-principles calculations via density functional theory. Especially, the superior photothermal-conversion performance (efficiency. of 44.7%) and in vitro/in vivo photothermal ablation of tumor by biocompatible soybean phospholipid-modified Ta4C3 nanosheets are systematically revealed and demonstrated. Based on the large family members of MXenes, this work may offer a paradigm that MXenes can achieve the specific biomedical applications (here, theranostic) providing that their compositions and nanostructures are carefully tuned and optimized to meet the strict requirements of biomedicine.
Keyworddual-mode imaging nanosheets photothermal therapy tantalum carbide theranostic
Subject AreaChemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
MOST Discipline CatalogueChemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
Funding OrganizationThe authors greatly acknowledge the financial support from the National Key R&D Program of China (Grant No. 2016YFA0203700), National Nature Science Foundation of China (Grant Nos. 51672303, 51722211), Young Elite Scientist Sponsorship Program by CAST (Grant No. 2015QNRC001), Youth Innovation Promotion Association of the Chinese Academy of Sciences (Grant No. 2013169), and Development Fund for Shanghai Talents (2015). Animal experimental procedures were in agreement with the guidelines of the Regional Ethics Committee for Animal Experiments and the care regulations approved by the administrative committee of laboratory animals of Fudan University. ; The authors greatly acknowledge the financial support from the National Key R&D Program of China (Grant No. 2016YFA0203700), National Nature Science Foundation of China (Grant Nos. 51672303, 51722211), Young Elite Scientist Sponsorship Program by CAST (Grant No. 2015QNRC001), Youth Innovation Promotion Association of the Chinese Academy of Sciences (Grant No. 2013169), and Development Fund for Shanghai Talents (2015). Animal experimental procedures were in agreement with the guidelines of the Regional Ethics Committee for Animal Experiments and the care regulations approved by the administrative committee of laboratory animals of Fudan University.
DOI10.1002/adma.201703284
Funding OrganizationThe authors greatly acknowledge the financial support from the National Key R&D Program of China (Grant No. 2016YFA0203700), National Nature Science Foundation of China (Grant Nos. 51672303, 51722211), Young Elite Scientist Sponsorship Program by CAST (Grant No. 2015QNRC001), Youth Innovation Promotion Association of the Chinese Academy of Sciences (Grant No. 2013169), and Development Fund for Shanghai Talents (2015). Animal experimental procedures were in agreement with the guidelines of the Regional Ethics Committee for Animal Experiments and the care regulations approved by the administrative committee of laboratory animals of Fudan University. ; The authors greatly acknowledge the financial support from the National Key R&D Program of China (Grant No. 2016YFA0203700), National Nature Science Foundation of China (Grant Nos. 51672303, 51722211), Young Elite Scientist Sponsorship Program by CAST (Grant No. 2015QNRC001), Youth Innovation Promotion Association of the Chinese Academy of Sciences (Grant No. 2013169), and Development Fund for Shanghai Talents (2015). Animal experimental procedures were in agreement with the guidelines of the Regional Ethics Committee for Animal Experiments and the care regulations approved by the administrative committee of laboratory animals of Fudan University.
WOS Subject2-DIMENSIONAL TITANIUM CARBIDE ; TRANSITION-METAL CARBIDES ; HIGH VOLUMETRIC CAPACITANCE ; IN-VIVO ; PHOTOTHERMAL THERAPY ; GRAPHENE OXIDE ; THIN-FILMS ; NANOSHEETS ; CONVERSION ; CANCER
WOS IDWOS:000422932800002
PublisherWILEY-V C H VERLAG GMBH
EI Accession Number1521-4095
Citation statistics
Document Type期刊论文
Identifierhttp://ir.sic.ac.cn/handle/331005/24537
Collection中国科学院上海硅酸盐研究所
Affiliation1.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Lin, Han,Wang, Youwei,Gao, Shanshan,et al. Theranostic 2D Tantalum Carbide (MXene)[J]. ADVANCED MATERIALS,2018,30(4).
APA Lin, Han,Wang, Youwei,Gao, Shanshan,Chen, Yu,&Shi, Jianlin.(2018).Theranostic 2D Tantalum Carbide (MXene).ADVANCED MATERIALS,30(4).
MLA Lin, Han,et al."Theranostic 2D Tantalum Carbide (MXene)".ADVANCED MATERIALS 30.4(2018).
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