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In vitro self-setting properties, bioactivity, and antibacterial ability of a silicate-based premixed bone cement
Xu, Chen1,2; Wen, Yang3,4,5; Zhou, Yanling1; Zhu, Yaqin3,4,5; Dou, Yuandong6; Huan, Zhiguang1; Chang, Jiang1
2018-03-01
Source PublicationINTERNATIONAL JOURNAL OF APPLIED CERAMIC TECHNOLOGY
Volume15Issue:2Pages:460-471
SubtypeArticle
AbstractThe clinical use of cements in root canal treatment needs the dentist to mix the powders and liquid phase thoroughly. The operation not only increases the surgery time but also compromises the performance of cement in case of inhomogeneous or insufficient mixing. To overcome those drawbacks, a premixed tricalcium silicate cement (C3S) was prepared by mixing tricalcium silicate/calcium chloride (C3S/CaCl2) composites with polyethylene glycol (PEG). It was found that the setting time could be modulated by changing the content of CaCl2 in the solid phase and the liquid to solid ratio (L/P). In addition, the premixed pastes retained the bioactivity of C3S, such as the ability to induce apatite formation in simulated oral fluid and to promote the proliferation and the alkaline phosphate (ALP) activity of human dental pulp stem cells (hDPSCs). Meanwhile, the injected pastes showed good antibacterial ability against Staphylococcus aureus. It is thus expected that the premixed C3S/CaCl2 pastes hold great promise as a new type of materials for dental application.
KeywordCalcium Chloride Dental Application Premixed Pastes Tricalcium Silicate
WOS HeadingsScience & Technology ; Technology
Funding OrganizationNational Natural Science Foundation of China(81190132 ; National Natural Science Foundation of China(81190132 ; 81401529) ; 81401529) ; National Natural Science Foundation of China(81190132 ; National Natural Science Foundation of China(81190132 ; 81401529) ; 81401529)
DOI10.1111/ijac.12813
WOS KeywordMINERAL TRIOXIDE AGGREGATE ; END FILLING MATERIALS ; ROOT-CANAL SEALERS ; TRICALCIUM SILICATE ; PHYSICAL-PROPERTIES ; ODONTOGENIC DIFFERENTIATION ; ANTIMICROBIAL ACTIVITY ; CALCIUM HYDROXIDE ; SEALING ABILITY ; DENTIN
Indexed BySCI
Language英语
WOS Research AreaMaterials Science
Funding OrganizationNational Natural Science Foundation of China(81190132 ; National Natural Science Foundation of China(81190132 ; 81401529) ; 81401529) ; National Natural Science Foundation of China(81190132 ; National Natural Science Foundation of China(81190132 ; 81401529) ; 81401529)
WOS SubjectMaterials Science, Ceramics
WOS IDWOS:000424816400021
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sic.ac.cn/handle/331005/24401
Collection生物材料与组织工程研究中心_期刊论文
Affiliation1.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai, Peoples R China
2.Univ Chinese Acad Sci, Beijing, Peoples R China
3.Shanghai Jiao Tong Univ, Peoples Hosp 9, Dept Gen Dent, Sch Med, Shanghai, Peoples R China
4.Natl Clin Res Ctr Stomatol, Shanghai Key Lab Stomatol, Shanghai, Peoples R China
5.Natl Clin Res Ctr Stomatol, Shanghai Res Inst Stomatol, Shanghai, Peoples R China
6.Yantai Zhenghai Biotech Co Ltd, Yantai, Peoples R China
Recommended Citation
GB/T 7714
Xu, Chen,Wen, Yang,Zhou, Yanling,et al. In vitro self-setting properties, bioactivity, and antibacterial ability of a silicate-based premixed bone cement[J]. INTERNATIONAL JOURNAL OF APPLIED CERAMIC TECHNOLOGY,2018,15(2):460-471.
APA Xu, Chen.,Wen, Yang.,Zhou, Yanling.,Zhu, Yaqin.,Dou, Yuandong.,...&Chang, Jiang.(2018).In vitro self-setting properties, bioactivity, and antibacterial ability of a silicate-based premixed bone cement.INTERNATIONAL JOURNAL OF APPLIED CERAMIC TECHNOLOGY,15(2),460-471.
MLA Xu, Chen,et al."In vitro self-setting properties, bioactivity, and antibacterial ability of a silicate-based premixed bone cement".INTERNATIONAL JOURNAL OF APPLIED CERAMIC TECHNOLOGY 15.2(2018):460-471.
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