SIC OpenIR  > 高性能陶瓷和超微结构国家重点实验室  > 期刊论文
In Vivo Targeted Cancer Theranostics by Core/Shell-Structured Multifunctional Prussian Blue/PLGA "Nanococktails"
Shang, Tingting1,2; Liu, Jianxin1,2,3; Chen, Yu4; Hu, Zicheng5; Deng, Liming1,2; Ran, Haitao1,2; Li, Pan1,2; Zheng, Yuanyi1,2,6; Wang, Dong7; Wang, Zhigang1,2; Sun, Yang1,2
2018-02-01
Source PublicationPARTICLE & PARTICLE SYSTEMS CHARACTERIZATION
Volume35Issue:2
SubtypeArticle
AbstractThe construction of high-performance nanotheranostic agent with Food and Drug Administration (FDA)-approved materials for efficient treatment of breast cancer is still of great challenge. This work reports, for the first time, on the elaborate integration of two FDA-approved materials together to construct a multifunctional core/shell-structured "nanococktail" for cancer theranostics. The biocompatible Prussian blue nanoparticles with high photothermal-conversion performance are coated by poly(lactic-co-glycolic acid) followed by further surface targeting engineering (folic acid conjugation). The anticancer drug paclitaxel is concurrently encapsulated into the nanocarrier with high efficiency and capacity. Especially, these "nanococktails" act as the desirable contrast agents for photoacoustic/magnetic resonance imaging dual-mode diagnostic imaging, providing the potential for guidance and monitoring during the therapeutic process, which has been systematically demonstrated both in vitro and in vivo. Importantly, these "nanococktails" have demonstrated their high performance in synergistic in vivo photothermal therapy and chemotherapy against breast cancer tumor xenograft. This work not only provides a high-performance theranostic "nanococktail" platform for efficient theranostic treatment of cancer but also paves a new way for the integration of various functional moieties together for realizing the specific diagnostic imaging-guided and synergistic cancer therapy.
KeywordNanomedicine Plga Prussian Blue Synergistic Therapy Theranostic
WOS HeadingsScience & Technology ; Physical Sciences ; Technology
Funding OrganizationNational Nature Science Foundation of China(81401423 ; National Nature Science Foundation of China(81401423 ; Chongqing Science & Technology Commission(cstc2016jcyjA0164) ; Chongqing Science & Technology Commission(cstc2016jcyjA0164) ; Chongqing foundation(cstc2014jcyjA10013) ; Chongqing foundation(cstc2014jcyjA10013) ; cutting-edge research projects(cstc2014jcyjA10013) ; cutting-edge research projects(cstc2014jcyjA10013) ; 81227801 ; 81227801 ; 81630047 ; 81630047 ; 31630026 ; 31630026 ; 81371578 ; 81371578 ; 81771845 ; 81771845 ; 81571688) ; 81571688) ; National Nature Science Foundation of China(81401423 ; National Nature Science Foundation of China(81401423 ; Chongqing Science & Technology Commission(cstc2016jcyjA0164) ; Chongqing Science & Technology Commission(cstc2016jcyjA0164) ; Chongqing foundation(cstc2014jcyjA10013) ; Chongqing foundation(cstc2014jcyjA10013) ; cutting-edge research projects(cstc2014jcyjA10013) ; cutting-edge research projects(cstc2014jcyjA10013) ; 81227801 ; 81227801 ; 81630047 ; 81630047 ; 31630026 ; 31630026 ; 81371578 ; 81371578 ; 81771845 ; 81771845 ; 81571688) ; 81571688)
DOI10.1002/ppsc.201700306
WOS KeywordBLUE NANOPARTICLES OPERATE ; BREAST-CANCER ; PHOTOTHERMAL THERAPY ; GOLD NANOPARTICLES ; CONTRAST AGENT ; TUMOR ; ABLATION ; NANOCRYSTALS ; CHEMOTHERAPY ; TOMOGRAPHY
Indexed BySCI
Language英语
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science
Funding OrganizationNational Nature Science Foundation of China(81401423 ; National Nature Science Foundation of China(81401423 ; Chongqing Science & Technology Commission(cstc2016jcyjA0164) ; Chongqing Science & Technology Commission(cstc2016jcyjA0164) ; Chongqing foundation(cstc2014jcyjA10013) ; Chongqing foundation(cstc2014jcyjA10013) ; cutting-edge research projects(cstc2014jcyjA10013) ; cutting-edge research projects(cstc2014jcyjA10013) ; 81227801 ; 81227801 ; 81630047 ; 81630047 ; 31630026 ; 31630026 ; 81371578 ; 81371578 ; 81771845 ; 81771845 ; 81571688) ; 81571688) ; National Nature Science Foundation of China(81401423 ; National Nature Science Foundation of China(81401423 ; Chongqing Science & Technology Commission(cstc2016jcyjA0164) ; Chongqing Science & Technology Commission(cstc2016jcyjA0164) ; Chongqing foundation(cstc2014jcyjA10013) ; Chongqing foundation(cstc2014jcyjA10013) ; cutting-edge research projects(cstc2014jcyjA10013) ; cutting-edge research projects(cstc2014jcyjA10013) ; 81227801 ; 81227801 ; 81630047 ; 81630047 ; 31630026 ; 31630026 ; 81371578 ; 81371578 ; 81771845 ; 81771845 ; 81571688) ; 81571688)
WOS SubjectChemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS IDWOS:000425641100003
Citation statistics
Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sic.ac.cn/handle/331005/24400
Collection高性能陶瓷和超微结构国家重点实验室_期刊论文
Affiliation1.Chongqing Med Univ, Chongqing Key Lab Ultrasound Mol Imaging, Affiliated Hosp 2, Inst Ultrasound Imaging, Chongqing 400010, Peoples R China
2.Chongqing Med Univ, Chongqing Key Lab Ultrasound Mol Imaging, Affiliated Hosp 2, Dept Ultrasound, Chongqing 400010, Peoples R China
3.Huazhong Univ Sci & Technol, Tongji Med Coll, Cent Hosp Wuhan, Ultrasound Dept, Wuhan 430014, Hubei, Peoples R China
4.Chinese Acad Sci, Shanghai Inst Ceram, State Lab High Performance Ceram & Superfine Micr, Shanghai 200050, Peoples R China
5.Chongqing Med Univ, Affiliated Hosp 1, Dept Neurol, Chongqing 400010, Peoples R China
6.Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 6, Shanghai Inst Ultrasound Med, Shanghai 200233, Peoples R China
7.Chongqing Med Univ, Dept Ultrasound, Affiliated Hosp 1, Chongqing 400010, Peoples R China
Recommended Citation
GB/T 7714
Shang, Tingting,Liu, Jianxin,Chen, Yu,et al. In Vivo Targeted Cancer Theranostics by Core/Shell-Structured Multifunctional Prussian Blue/PLGA "Nanococktails"[J]. PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION,2018,35(2).
APA Shang, Tingting.,Liu, Jianxin.,Chen, Yu.,Hu, Zicheng.,Deng, Liming.,...&Sun, Yang.(2018).In Vivo Targeted Cancer Theranostics by Core/Shell-Structured Multifunctional Prussian Blue/PLGA "Nanococktails".PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION,35(2).
MLA Shang, Tingting,et al."In Vivo Targeted Cancer Theranostics by Core/Shell-Structured Multifunctional Prussian Blue/PLGA "Nanococktails"".PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION 35.2(2018).
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