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Hydroxyapatite nanorod-assembled porous hollow polyhedra as drug/protein carriers
Yu, Ya-Dong1,2; Zhu, Ying-Jie1,2; Qi, Chao1; Jiang, Ying-Ying1,2; Li, Heng1,2; Wu, Jin1
2017-06-15
Source PublicationJOURNAL OF COLLOID AND INTERFACE SCIENCE
Volume496Pages:416-424
SubtypeArticle
AbstractHydroxyapatite (HAP) with a porous hollow structure is an ideal biomaterial owing to its excellent biocompatibility and unique architecture. In this study, HAP nanorod-assembled porous hollow polyhedra, consisting of nanorod building blocks, have been successfully prepared at room temperature or under hydrothermal circumstances using a self-sacrificing Ca(OH)(2) template strategy. The hydrothermal treatment (at 180 degrees C for 1 h) can promote the HAP nanorods to be arranged with their axial direction normal to the polyhedron surface. The HAP nanorod-assembled porous hollow polyhedra have been explored for the potential application in drug/protein delivery, using ibuprofen (IBU) as a model drug and hemoglobin (Hb) as a model protein. The experimental results indicate that the HAP nanorod-assembled porous hollow polyhedra have a relatively high drug loading capacity and protein adsorption ability, and sustained drug and protein release. The HAP nanorod-assembled porous hollow polyhedra have promising applications in various biomedical fields such as the drug and protein delivery.(C) 2017 Elsevier Inc. All rights reserved.
KeywordHydroxyapatite Biomaterials Hydrothermal Drug Delivery Protein Adsorption
WOS HeadingsScience & Technology ; Physical Sciences
Funding OrganizationNational Natural Science Foundation of China(51302294) ; National Natural Science Foundation of China(51302294) ; National Natural Science Foundation of China(51302294) ; National Natural Science Foundation of China(51302294) ; Science and Technology Commission of Shanghai(15JC1491001) ; Science and Technology Commission of Shanghai(15JC1491001) ; Science and Technology Commission of Shanghai(15JC1491001) ; Science and Technology Commission of Shanghai(15JC1491001) ; National Natural Science Foundation of China(51302294) ; National Natural Science Foundation of China(51302294) ; National Natural Science Foundation of China(51302294) ; National Natural Science Foundation of China(51302294) ; Science and Technology Commission of Shanghai(15JC1491001) ; Science and Technology Commission of Shanghai(15JC1491001) ; Science and Technology Commission of Shanghai(15JC1491001) ; Science and Technology Commission of Shanghai(15JC1491001)
DOI10.1016/j.jcis.2017.02.041
WOS KeywordORGANIC PHOSPHORUS SOURCE ; DRUG-DELIVERY ; PROTEIN ADSORPTION ; HYDROTHERMAL SYNTHESIS ; CREATINE-PHOSPHATE ; RAPID SYNTHESIS ; WATER-TREATMENT ; GENE DELIVERY ; MICROSPHERES ; BONE
Indexed BySCI
Language英语
WOS Research AreaChemistry
Funding OrganizationNational Natural Science Foundation of China(51302294) ; National Natural Science Foundation of China(51302294) ; National Natural Science Foundation of China(51302294) ; National Natural Science Foundation of China(51302294) ; Science and Technology Commission of Shanghai(15JC1491001) ; Science and Technology Commission of Shanghai(15JC1491001) ; Science and Technology Commission of Shanghai(15JC1491001) ; Science and Technology Commission of Shanghai(15JC1491001) ; National Natural Science Foundation of China(51302294) ; National Natural Science Foundation of China(51302294) ; National Natural Science Foundation of China(51302294) ; National Natural Science Foundation of China(51302294) ; Science and Technology Commission of Shanghai(15JC1491001) ; Science and Technology Commission of Shanghai(15JC1491001) ; Science and Technology Commission of Shanghai(15JC1491001) ; Science and Technology Commission of Shanghai(15JC1491001)
WOS SubjectChemistry, Physical
WOS IDWOS:000398425800045
Citation statistics
Cited Times:7[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sic.ac.cn/handle/331005/23774
Collection生物材料与组织工程研究中心_期刊论文
Affiliation1.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Yu, Ya-Dong,Zhu, Ying-Jie,Qi, Chao,et al. Hydroxyapatite nanorod-assembled porous hollow polyhedra as drug/protein carriers[J]. JOURNAL OF COLLOID AND INTERFACE SCIENCE,2017,496:416-424.
APA Yu, Ya-Dong,Zhu, Ying-Jie,Qi, Chao,Jiang, Ying-Ying,Li, Heng,&Wu, Jin.(2017).Hydroxyapatite nanorod-assembled porous hollow polyhedra as drug/protein carriers.JOURNAL OF COLLOID AND INTERFACE SCIENCE,496,416-424.
MLA Yu, Ya-Dong,et al."Hydroxyapatite nanorod-assembled porous hollow polyhedra as drug/protein carriers".JOURNAL OF COLLOID AND INTERFACE SCIENCE 496(2017):416-424.
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