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Preparation and in vitro osteogenic, angiogenic and antibacterial properties of cuprorivaite (CaCuSi4O10, Cup) bioceramics
Tian, Tian; Wu, Chengtie; Chang, Jiang
2016
Source PublicationRSC ADVANCES
Volume6Issue:51Pages:45840-45849
SubtypeArticle
Abstract

For better tissue regeneration, the combination of beneficial inorganic ions may provide a more effective and safer strategy to couple with multi-functions (such as osteogenesis, angiogenesis and antibacterial activity) as compared with growth factors. Previous studies have demonstrated that Si ions released from silicate bioceramics could promote osteogenesis and angiogenesis. Divalent copper ions (Cu2+) were widely reported to enhance angiogenesis and possess antibacterial activity. Therefore, we hypothesize that the combination of Cu and Si ions may reveal better osteogenic, angiogenic and antibacterial activity. In this study, we synthesized a Cu-containing silicate bioceramic, cuprorivaite (CaCuSi4O10, Cup) and investigated its in vitro osteogenic, angiogenic and antibacterial capacities. We, for the first time, successfully synthesized Cup powders with high-purity by sol-gel method. In vitro biological evaluation indicated that ionic dissolution products of Cup ceramics in the concentration range of 0.195-0.78 mg mL(-1) were able to significantly promote angiogenesis. More importantly, Si and Cu ions had a synergistic effect on angiogenesis at lower concentrations compared with those reported in the literature. Moreover, Cup ceramics had good antibacterial activity. However, ionic dissolution products of Cup ceramics at 0.195-0.78 mg mL(-1) notably suppressed ALP activity of osteoblast-like cells. Therefore, Cup bioceramics may have a potential application in wound healing, but may not be suitable for bone regeneration.

WOS HeadingsScience & Technology ; Physical Sciences
Funding OrganizationNatural Science Foundation of China(81430012 ; Queensland-Chinese Academy of Sciences (Q-CAS) Collaborative Science Fund ; 81190132) ; Natural Science Foundation of China(81430012 ; Queensland-Chinese Academy of Sciences (Q-CAS) Collaborative Science Fund ; 81190132)
DOI10.1039/c6ra08145b
WOS KeywordBIOACTIVE GLASS SCAFFOLDS ; HUMAN ENDOTHELIAL-CELLS ; MESENCHYMAL STEM-CELLS ; EGYPTIAN BLUE ; CALCIUM SILICATE ; COPPER ; BONE ; IMPLANTS ; CULTURE ; STIMULATION
Indexed BySCI
Language英语
WOS Research AreaChemistry
Funding OrganizationNatural Science Foundation of China(81430012 ; Queensland-Chinese Academy of Sciences (Q-CAS) Collaborative Science Fund ; 81190132) ; Natural Science Foundation of China(81430012 ; Queensland-Chinese Academy of Sciences (Q-CAS) Collaborative Science Fund ; 81190132)
WOS SubjectChemistry, Multidisciplinary
WOS IDWOS:000376120100104
Citation statistics
Cited Times:25[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sic.ac.cn/handle/331005/23084
Collection生物材料与组织工程研究中心_期刊论文
AffiliationChinese Acad Sci, Shanghai Inst Ceram, Biomat & Tissue Engn Res Ctr, Shanghai 200050, Peoples R China
Recommended Citation
GB/T 7714
Tian, Tian,Wu, Chengtie,Chang, Jiang. Preparation and in vitro osteogenic, angiogenic and antibacterial properties of cuprorivaite (CaCuSi4O10, Cup) bioceramics[J]. RSC ADVANCES,2016,6(51):45840-45849.
APA Tian, Tian,Wu, Chengtie,&Chang, Jiang.(2016).Preparation and in vitro osteogenic, angiogenic and antibacterial properties of cuprorivaite (CaCuSi4O10, Cup) bioceramics.RSC ADVANCES,6(51),45840-45849.
MLA Tian, Tian,et al."Preparation and in vitro osteogenic, angiogenic and antibacterial properties of cuprorivaite (CaCuSi4O10, Cup) bioceramics".RSC ADVANCES 6.51(2016):45840-45849.
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